Principal Investigator · Assistant Professor
Matthias Walle, PhD
I am an Assistant Professor in the Department of Radiology at the University of Calgary. Our lab is based in the McCaig Institute for Bone and Joint Health. I work at the intersection of medical imaging, computational modelling, and musculoskeletal research. My research examines how the mechanical environment influences tissue behaviour using imaging and simulation methods.
I completed my PhD at ETH Zurich, where I received the ETH Medal for my work on bone health in diabetes and developed methods to study bone adaptation using longitudinal high-resolution imaging. At the University of Calgary, I combine medical imaging, finite element modelling, and machine learning to study bone metastases, spinal alignment, and bone mechanobiology.
My work spans method development, clinical applications, and open research software, including the Bone Imaging Toolbox for 3D Slicer. Students can work across these areas, from developing an analysis method to using it to address a biological or clinical question.
Education & research training
- Bachelor's degree — Technical University of Munich (TUM).
- Master's thesis — Harvard Medical School.
- PhD — ETH Zurich. Awarded the ETH Medal.