RESEARCH
Cancer–Bone Mechanobiology
Investigating how bone metastases and the mechanical environment influence one another, and how to quantify treatment response.
Bone metastases change tissue structure and the ability of bone to carry load. We are investigating how those changes relate to tumour growth, the response of the surrounding tissue, and treatment response during immune checkpoint inhibitor therapy.
The mechanobiology component connects image-derived structure and texture with estimates of local mechanical conditions. Questions include whether muscle-generated loading contributes to differences in the environment of metastatic lesions.
Imaging and response assessment
We aim to develop bone-specific measures of progression and response. Potential methods include deep-learning segmentation, radiomics, validated radiology-report analysis, and image-based finite element simulations.
This bone-metastasis work is ongoing and has no published results yet. Student project scope, datasets, supervision, and funding will be confirmed individually.