Bone mechanobiology in diabetes

Why can bone health be impaired even when density does not tell the whole story? This work studies bone remodelling and responsiveness to mechanical stimuli in people with type 1 diabetes.

Longitudinal high-resolution imaging identifies formation and resorption sites. Image-based mechanical models then let us examine how those sites relate to the local mechanical environment.

This application connects disease biology with tissue-level adaptation and builds on Matthias's PhD work on bone health in diabetes, recognised with the ETH Medal.

Read the mechanobiology study and the diabetes bone-structure meta-analysis.